Age of Apocalypse
- Characters: Morph, Shadowcat, Holocaust, Dark Beast, Blink, X-Man
- Inherent: Age of Apocalypse Team +2 to venture total per battle if using "Age of Apocalypse" mission with at least 1 event card.
The Big Apple
- Characters: Heroes for hire, Falcon, Thunderbolts, Daredevil, Spider-Man, Morbius
- Inherent: Big Apple Team begins game with 6 mission cards in reserve missions pile and 1 mission card in defeated missions pile.
- Characters: Hulk, She-Hulk, Doc Samson, Leader, Abomination, Thunderbolts
- Inherent: Gamma Base Team -2 to venture total per battle if opponent is using "Annihilation Affair" Mission.
- Characters: Abomination, Morlocks, Venom, The Mole Man, Lizard, Angel
- Interent: The Swer Team's Intellect Power cards +2 for defense.
- Characters: Black Panther, Dr. Doom, Vision, Hawkeye, Storm, Klaw
- Inherent: Wakanda Team's MultiPower power cards are -1 to attack.
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